منابع مشابه
EJE PRIZE 2017: Hypothalamic AMPK: a golden target against obesity?
AMP-activated protein kinase (AMPK) is a cellular gauge that is activated under conditions, such as low energy, increasing energy production and reducing energy waste. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, with neuronal networks. Current evidence links hypothalamic AMPK with feeding, b...
متن کاملCHIP protects against cardiac pressure overload through regulation of AMPK.
Protein quality control and metabolic homeostasis are integral to maintaining cardiac function during stress; however, little is known about if or how these systems interact. Here we demonstrate that C terminus of HSC70-interacting protein (CHIP), a regulator of protein quality control, influences the metabolic response to pressure overload by direct regulation of the catalytic α subunit of AMP...
متن کاملAmpk
What does it do? AMPK has been dubbed the cellular fuel gauge, because it is activated by a drop in the energy status of the cell. If ATP is used up faster than it can be re-synthesized, ATP levels fall and this leads to a rise in AMP. The increase in the AMP:ATP ratio triggers the activation of AMPK and leads to the phosphorylation of a large number of downstream targets. The overall effect of...
متن کاملAmpk
Ion transport processes are highly energy consuming. It is therefore critical to couple ion transport processes to the metabolic state of the cell. An important player in this coupling appears to be the AMP-activated protein kinase (AMPK). This kinase becomes activated during conditions of cellular metabolic stress and is well-known for its role in promoting ATP-generating catabolic pathways wh...
متن کاملBeyond Nash Bargaining Theory: The Nash Set*
We extend Nash's bargaining theory to non-convex and coalitional problems. This paper investigates the implications of Nash-like axioms for bilateral problems and the properties of consistency and converse consistency over multilateral settings. The result is a characterization of the Nash set of NTU games, defined as the solution concept where each pair of players is splitting the gains from t...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2020
ISSN: 1471-0072,1471-0080
DOI: 10.1038/s41580-020-0225-0